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Largest-Yet Mesothelioma Study Shows Survival Bene
By: Govt
Researchers with the largest phase III trial
to date for mesothelioma, an aggressive cancer affecting the lining of
the lung, reported results showing that patients on a new chemotherapy
drug regimen
live longer and have less pain than those on an older drug. The
findings were announced at the annual meeting of the American Society
of Clinical Oncology meeting in Orlando, Fla., on May 20, 2002.
Pemetrexed
(brand name Alimtaô) is a novel antifolate, a class of drugs that
targets the folic acid metabolic pathway, which effects availability of
certain B complex vitamins. The results of the trial show that tumors
shrank in 41 percent of patients on pemetrexed in combination with a
more commonly used chemotherapy agent called cisplatin.
Only 17 percent of patients receiving cisplatin alone experienced tumor
shrinkage. Additionally, those on the pemetrexed combination lived
nearly three months longer than those on cisplatin alone.
According
to lead author, Nicholas J. Vogelzang, M.D., University of Chicago
Cancer Research Center, "This is the largest clinical trial ever
conducted in this disease and the 25 to 30 percent improvement in
survival for patients on the combination therapy is the first time
anyone has documented a significant improvement in patients treated for
mesothelioma."
Malignant pleural mesothelioma is associ....[MORE]
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