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Largest-Yet Mesothelioma Study Shows Survival Bene
By: Govt
Researchers with the largest phase III trial
to date for mesothelioma, an aggressive cancer affecting the lining of
the lung, reported results showing that patients on a new chemotherapy
drug regimen
live longer and have less pain than those on an older drug. The
findings were announced at the annual meeting of the American Society
of Clinical Oncology meeting in Orlando, Fla., on May 20, 2002.
Pemetrexed
(brand name Alimtaô) is a novel antifolate, a class of drugs that
targets the folic acid metabolic pathway, which effects availability of
certain B complex vitamins. The results of the trial show that tumors
shrank in 41 percent of patients on pemetrexed in combination with a
more commonly used chemotherapy agent called cisplatin.
Only 17 percent of patients receiving cisplatin alone experienced tumor
shrinkage. Additionally, those on the pemetrexed combination lived
nearly three months longer than those on cisplatin alone.
According
to lead author, Nicholas J. Vogelzang, M.D., University of Chicago
Cancer Research Center, "This is the largest clinical trial ever
conducted in this disease and the 25 to 30 percent improvement in
survival for patients on the combination therapy is the first time
anyone has documented a significant improvement in patients treated for
mesothelioma."
Malignant pleural mesothelioma is associated with a history of asbestos
exposure in about 70 to 80 percent of all cases and there is no
approved or very effective chemotherapy for the disease. Researchers
hypothesized that pemetrexed might prove effective in treating this
disease because it targets key enzymes (molecules that speed up
chemical reactions in the body) thought to play a role in allowing the
rapid growth of this tumor.
Early phase I trial results in 11 patients tested with pemetrexed and cisplatin were promising and a definitive randomized
phase III trial was developed. Since there are no established therapies
for this condition, a standard chemotherapy agent called cisplatin that
has shown efficacy in treating other diseases, was used as the [MORE]
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| Mesothelioma Advice: The leading mesothelioma resource site. A valuable resource about mesothelioma, a rare form of cancer caused by asbestos exposure, including advice on how to choose a medical care team. ... About Mesothelioma. Medical Care ... caused by exposure to asbestos, mesothelioma tragically affects thousands of American ... We've been working with mesothelioma families for more than a ...
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| Mesothelioma - Chrysotile ... Webster's. Mesothelioma. Dictionary. Synonyms: Chrysotile ... chemistry), fibrous serpentine (chemistry), serpentine asbestos (chemistry). Top. Definition: Chrysotile. Chrysotile ...
[see more on Mesothelioma - Chrysotile]
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| Chrysotile Peritoneal Mesothelioma - Asbestos Cancer Resource Mesothelioma resource provides information about chrysotile peritoneal mesothelioma, a malignant asbestos cancer. ... Chrysotile Peritoneal Mesothelioma. Chrysotile Mesothelioma is also related to asbestos ...
[see more on Chrysotile Peritoneal Mesothelioma - Asbestos Cancer Resource]
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| Mesothelioma Researchers Call for Ban on Chrysotile Asbestos ... | SurvivingMesothelioma.com reports that the Nelson Institute for Environmental Studies at the University of Wisconsin has concluded that chrysotile asbestos ... | http://news.yahoo.com/mesothelioma-researchers-call-ban-chrysotile-asbestos-according-surv ivingmesothelioma-071207610.html | | | | Chrysotile Mesothelioma.net | | For Your FREE Consultation CALL NOW: 1-888-808-5977 Chrysotile Mesothelioma. Unfortunately, medicine still has some mysteries and one of them is mesothelioma, an ... | | http://www.chrysotilemesothelioma.net/ | | | | The Risk of Mesothelioma with Chrysotile Exposure | Chrysotile is a serpentine mineral belonging to the asbestiform sub-group. It is a material from which asbestos is produced. It can be found in Canada ... | | http://ezinearticles.com/?The-Risk-of-Mesothelioma-with-Chrysotile-Exposure&id=689951 | | | | Mesothelioma - Chrysotile Peritoneal Mesothelioma | Crysotile Peritonia Mesothelioma. Symptoms and Diagnosis of Crysotile Peritoneal Mesothelioma. Information about Crysotile Peritonia Mesothelioma Cancer. | | http://abcmesotheliomacancer.com/chrysotile_peritoneal_mesothelioma.html | | | | Chrysotile - Mesothelioma Cancer Resources | Chrysotile Exposure, the risk of Mesothelioma. What is Chrysotile? Chrysotile is a serpentine mineral belonging to the asbestiform sub-group. Actually, it is a ... | | http://mesotheliomaz.info/chrysotile.html | | |
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