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Largest-Yet Mesothelioma Study Shows Survival Bene
By: Govt
Researchers with the largest phase III trial
to date for mesothelioma, an aggressive cancer affecting the lining of
the lung, reported results showing that patients on a new chemotherapy
drug regimen
live longer and have less pain than those on an older drug. The
findings were announced at the annual meeting of the American Society
of Clinical Oncology meeting in Orlando, Fla., on May 20, 2002.
Pemetrexed
(brand name Alimtaô) is a novel antifolate, a class of drugs that
targets the folic acid metabolic pathway, which effects availability of
certain B complex vitamins. The results of the trial show that tumors
shrank in 41 percent of patients on pemetrexed in combination with a
more commonly used chemotherapy agent called cisplatin.
Only 17 percent of patients receiving cisplatin alone experienced tumor
shrinkage. Additionally, those on the pemetrexed combination lived
nearly three months longer than those on cisplatin alone.
According
to lead author, Nicholas J. Vogelzang, M.D., University of Chicago
Cancer Research Center, "This is the largest clinical trial ever
conducted in this disease and the 25 to 30 percent improvement in
survival for patients on the combination therapy is the first time
anyone has documented a significant improvement in patients treated for
mesothelioma."
Malignant pleural mesothelioma is associated with a history of asbestos
exposure in about 70 to 80 percent of all cases and there is no
approved or very effective chemotherapy for the disease. Researchers
hypothesized that pemetrexed might prove effective in treating this
disease because it targets key enzymes (molecules that speed up
chemical reactions in the body) t....[MORE]
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| Mesothelioma Fact Sheet - American Lung Association site Mesothelioma Fact Sheet. April 2003. Mesothelioma is a rare form of cancer that involves the mesothelium, or cells that line an organ, usually the lungs, abdominal organs, and heart. ... Home > Diseases A to Z > Diseases Index > Diseases M - R > Mesothelioma Fact Sheet ... Lung Disease Data in Culturally Diverse Communities. Mesothelioma Fact Sheet ...
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| National Cancer Institute - Mesothelioma: Questions and Answers A fact sheet about the risk factors, symptoms, diagnosis, and treatment of mesothelioma. National Cancer Institute Fact Sheet 6.36 ... View/Print PDF. Search Fact Sheets by Keyword ... Mesothelioma is a rare form of cancer in which malignant (cancerous) cells are found in the mesothelium, a protective ...
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| Home - American Lung Association site View the TV Spot. Find out what an asthma attack sounds like. Take the Test! Five simple questions to help you better control your asthma. Lung Champions
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| Asbestos Mesothelioma Cancer attorney and lawyer help informational guide Asbestos Mesothelioma lawyer and attorney informational resources guide addresses mesothelioma symptoms, treatment options, diagnosis, clinical trials, chrysotile asbestos cancer treatment and its exposure. ... Mesothelioma. Mesothelioma Fact. Mesothelioma Symptom. Mesothelioma Diagnosis. Mesothelioma Causes. Malignant Mesothelioma. Mesothelioma Stage. Pleural Mesothelioma ... Pericardial Mesothelioma ...
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| Mesothelioma Information Facts & FAQs Newsletter: Kazan ... | Mesothelioma Types: Pleural mesothelioma Peritoneal mesothelioma Other mesotheliomas Diagnosis & screening. Mesothelioma Treatments: Multimodeal treatment | | http://www.mesothelioma-facts.com/ | | | | Mesothelioma Statistics & Facts | Mesothelioma Statistics & Facts. Question the general public about the cancer known as mesothelioma and you'll probably find that few individuals know little or anything at all about ... | | http://www.asbestos.com/mesothelioma/statistics.php | | |
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