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Largest-Yet Mesothelioma Study Shows Survival Bene
By: Govt
Researchers with the largest phase III trial
to date for mesothelioma, an aggressive cancer affecting the lining of
the lung, reported results showing that patients on a new chemotherapy
drug regimen
live longer and have less pain than those on an older drug. The
findings were announced at the annual meeting of the American Society
of Clinical Oncology meeting in Orlando, Fla., on May 20, 2002.
Pemetrexed
(brand name Alimtaô) is a novel antifolate, a class of drugs that
targets the folic acid metabolic pathway, which effects availability of
certain B complex vitamins. The results of the trial show that tumors
shrank in 41 percent of patients on pemetrexed in combination with a
more commonly used chemotherapy agent called cisplatin.
Only 17 percent of patients receiving cisplatin alone experienced tumor
shrinkage. Additionally, those on the pemetrexed combination lived
nearly three months longer than those on cisplatin alone.
According
to lead author, Nicholas J. Vogelzang, M.D., University of Chicago
Cancer Research Center, "This is the largest clinical trial ever
conducted in this disease and the 25 to 30 percent improvement in
survival for patients on the combination therapy is the first time
anyone has documented a significant improvement in patients treated for
mesothelioma."
Malignant pleural mesothelioma is associated with a history of asbestos
exposure in about 70 to 80 percent of all cases and there is no
approved or very effective chemotherapy for the disease. Researchers
hypothesized that pemetrexed might prove effective in treating this
disease because it targets key enzymes (molecules that speed up
chemical reactions in the body) thought to play a role in allowing the
rapid growth of this tumor.
Early phase I trial results in 11 patients tested with pemetrexed and cisplatin were promising and a definitive randomized
phase III trial was developed. Since there are no established therapies
....[MORE]
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| MesoLink.org -- Your Link To Mesothelioma Information Welcome To MesoLink.org... Your Link To Mesothelioma Information. Mesothelioma is one of the deadliest diseases known to man; the average life span of an inflicted person from the time of diagnosis until death is less than 24 months.
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| Mesothelioma Source - Resource for Asbestos Cancer Mesothelioma Source offers comprehensive information on types, stages and treatment of malignant mesothelioma ... What is mesothelioma? Mesothelioma is a form of cancer affecting the abdominal cavity, chest cavity ... Due to its uncommon nature, mesothelioma is typically difficult to diagnose and ...
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| Mesothelioma & Asbestos Cancer Resource ... What is Mesothelioma? Mesothelioma is a rare disease caused as a result of malignant cancerous cells lining ... many as 70-80% of all mesothelioma cases. This disease is very ...
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| Mesothelioma - Wikipedia, the free encyclopedia | Mesothelioma (or, more precisely, malignant mesothelioma) is a rare form of cancer that develops from transformed cells originating in the mesothelium, the protective ... | | http://en.wikipedia.org/wiki/Mesothelioma | | | | Mesothelioma - Cancer Types, Causes, Symptoms and Diagnosis | Mesothelioma Cancer information and research on cancer types, causes, symptoms and diagnosis. | | http://www.mesothelioma.com/mesothelioma/ | | | | Mesothelioma Cancer Alliance | The Authority on Asbestos Cancer | Mesothelioma treatment, diagnosis and related information for patients and families. Legal options for those diagnosed with malignant mesothelioma. | | http://www.mesothelioma.com/ | | | | Mesothelioma: The Mesothelioma Association: A Complete Cancer Guide | Mesothelioma. Receiving a diagnosis of mesothelioma can be frightening and overwhelming, but the Mesothelioma Association can help guide you and your loved ones to ... | | http://www.mesothelioma.as/ | | | | Mesothelioma Attorney Houston | Texas Asbestos Lawsuit | Heard ... | Heard Robins Cloud & Black, LLP are experienced Asbestos lawyers who represent clients with Mesothelioma cases. Our Asbestos attorneys serve Houston, Beaumont, and ... | | http://www.texas-mesothelioma-lawyers.com/ | | | | Mesothelioma Cancer | Symptoms of Mesothelioma Information | Mesothelioma Resource Online has created and developed this site to provide answers and support for people diagnosed with mesothelioma cancer, as well as their ... | | http://www.mesotheliomasymptoms.com/ | | |
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