Pleural Mesothelioma Web Directory, and Resources

Pleural Mesothelioma Resources

This site contains resources and articles for you to use when you are looking for information about pleural mesothelioma. This site has articles, links to pleural mesothelioma, information and news. In the future we will have reviews of products that will help you make your decision easier with pleural mesothelioma, so you can save time

Featured Pleural Mesothelioma Article

Mesothelioma Standard Treatment Options II

By: Govt

Standard treatment options:

1. Symptomatic treatment to include drainage of effusions, chest tube pleurodesis, or thoracoscopic pleurodesis.
2. Palliative surgical resection in selected patients.
3. Palliative radiation therapy.
4. Single-agent chemotherapy. Partial responses have been reported with doxorubicin, epirubicin, mitomycin, cyclophosphamide, cisplatin, carboplatin, and ifosfamide.
5. Combination chemotherapy (under clinical evaluation). Information about ongoing clinical trials is available from the NCI Cancer.gov Website.
6. Multimodality clinical trials.
7. Intracavitary therapy. Intrapleural or intraperitoneal administration of chemotherapeutic agents (e.g., cisplatin, mitomycin, and cytarabine) has been reported to produce transient reduction in the size of tumor masses and temporary control of effusions in small clinical studies. Additional studies are needed to define the role of intra-cavitary therapy.

The safety and efficacy of pemetrexed, an antifolate, and cisplatin in chemotherapy-n aive patients with malignant mesothelioma who were not eligible for curative surgery was demonstrated in a large phase III randomized trial. This trial compared pemetrexed (500 mg/m²) and cisplatin (75 mg/m² on day 1) with cisplatin alone (75 mg/m² on day 1 intravenously every 21 days). A total of 456 patients were enrolled: 226 patients received pemetrexed plus cisplatin and 222 patients received cisplatin alone; 8 patients did not receive therapy. After 117 patients had enrolled, folic acid and vitamin B₁₂ were added to reduce toxic effects. Folic acid (350-1,000 µg orally) was given daily, beginning 1 to 3 weeks before the first chemotherapy dose and continuing daily until 1 to 3 weeks after treatment ended. A vi tamin B₁₂ injection (1,000 µg intramusc....[MORE]

Sponsored Pleural Mesothelioma Resources

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