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Author: Maggie Kay

Thereís a silent killer out there. It creeps up on its victims, attacks them quietly and unsuspectingly, and initiates a wound that develops over many years before it eventually causes pain. This unstoppable murderer is known as mesothelioma.

Mesothelioma is a malignant tumor that develops on the mesothelial cells of either the lungs, heart or abdominal organs, and plagues those who have been exposed to asbestos for a prolonged period of time. Many who fall victim to this disease are people who have worked in specific trades or fields prior to the 1970s, such as blacksmiths, electricians, millwrights, and oil refinery workers.

Since it can take up to forty years for symptoms to surface, mesothelioma-related deaths are higher than ever in the 21st century. The Centers for Disease Control and Prevention state that 1,493 people died from asbestos in 2000, compared to 77 people in 1968.

Mesothelioma treatment methods differ depending on the stage of the cancer upon detection, as well as....[MORE]

Author:

Standard treatment

options:

1. Symptomatic treatment to include drainage of effusions,

   chest tube

   pleurodesis, or thoracoscopic pleurodesis.

2. Palliative surgical resection

   in selected patients.

3. Palliative radiation therapy.
4. Single-agent chemotherapy. Partial responses have been reported with

   doxorubicin, epirubicin, mitomycin, cyclophosphamide, cisplatin, carboplatin,

   and ifosfamide.

5. Combination chemotherapy (under clinical evaluation). Information

   about ongoing clinical trials is available from the NCI

   Cancer.gov Website.

6. Multimodality clinical trials.
7. Intracavitary

   therapy. Intrapleural or intraperitoneal administration

   of

   chemotherapeutic agents (e.g., cisplatin, mitomycin,

   and cytarabine) has been

   reported to produce transient

   reduction in the size of tumor masses and

   temporary control of effusions in small clinical studies. Additional

   studies are needed to define the role of intra-cavitary therapy.

The safety and efficacy of pemetrexed, an antifolate, and

cisplatin in chemotherapy-n aive patients with malignant mesothelioma

who were not eligible fo....[MORE]

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